Two young "hippie" bikers, Wyatt and Billy sell some dope in Southern California, stash their money away in their gas-tank and set off for a trip across America, on their own personal odyssey looking for a way to lead their lives. On the journey they encounter bigotry and hatred from small-town communities who despise and fear their non-conformism. However Wyatt and Billy also discover people attempting 'alternative lifestyles' who are resisting this narrow-mindedness, there is always a question mark over the future survival of these drop-out groups. The gentle hippie community who thank God for 'a place to stand' are living their own unreal dream. The rancher they encounter and his Mexican wife are hard-pushed to make ends meet. Even LSD turns sour when the trip is a bad one. Death comes to seem the only freedom. When they arrive at a diner in a small town, they are insulted by the local rednecks as weirdo degenerates. They are arrested on some minor pretext by the local sheriff and thrown in jail where they meet George Hanson, a liberal alcoholic lawyer. He gets them out and decides to join them on their trip to New Orleans in time for Mardi Gras.
Paranoid Brigadier General Jack D. Ripper of Burpelson Air Force Base, believing that fluoridation of the American water supply is a Soviet plot to poison the US. populace, is able to deploy through a back door mechanism a nuclear attack on the Soviet Union without the knowledge of his superiors, including the Chair of the Joint Chiefs of Staff, General Buck Turgidson, and President Merkin Muffley. Only Ripper knows the code to recall the B-52 bombers and he has shut down communication in and out of Burpelson as a measure to protect this attack. Ripper's executive officer, RAF Group Captain Lionel Mandrake (on exchange from Britain), who is being held at Burpelson by Ripper, believes he knows the recall codes if he can only get a message to the outside world. Meanwhile at the Pentagon War Room, key persons including Muffley, Turgidson and nuclear scientist and adviser, a former Nazi named Dr. Strangelove, are discussing measures to stop the attack or mitigate its blow-up into an all.